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表、蔬食的飲食模式預防和治療帕金森氏症
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預防
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帕金森氏症的風險
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備註
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一
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多吃富含黃酮類的水果蔬菜明顯降低帕金森氏症的風險
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49,281美國人 追蹤20-22年
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1. 男人吃植物黃酮類(flavonoids)最多者比吃最少一組
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↓40%
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Neurology 2012;
78:1138-1145.
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2. 男人吃蘋果每週5份或以上者比吃最少一組
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↓46%
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3. 男女吃富含花青素的草莓和藍莓每週2-4份者比吃最少一組
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↓23%
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4. 男女喝紅酒無助於降低帕金森氏症的風險
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-
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二
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多喝咖啡顯著降低帕金森氏症的風險
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112,122美國人
追蹤
18年
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1. 男人每天喝2杯含咖啡因的咖啡
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↓46%
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Movement Disorders 2012; 27:1276-1282
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2. 女人每天喝2杯含咖啡因的咖啡
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↓31%
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3. 去咖啡因的咖啡與帕金森氏症的風險無關
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-
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63,257新加坡華人
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4. 華人每天喝2杯含咖啡因的咖啡
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↓22%
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Am J Epidemiol 2008;167:553-560
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249患者日本人
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5. 日本人喝咖啡最多者比喝最少一組
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↓48%
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Parkinsonism & related Disorders 2011;17:446-450
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三
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多喝茶顯著降低帕金森氏症的風險
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63,257新加坡華人
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1. 華人喝紅茶最多一組比喝最少一組
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↓71%
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Am J Epidemiol 2008;167:553-560
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2. 華人吃單元不飽和脂肪、維生素E、異硫氰酸酯最多一組顯著降低罹患帕金森氏症的風險
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249患者日本人
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3. 日本人喝紅茶最多一組比喝最少一組
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↓42%
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Parkinsonism & related Disorders 2011;17:446-450
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4. 日本人喝日本綠茶和中國烏龍茶最多一組比喝最少一組
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↓41%
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治療
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備註
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一
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吃純蔬食4週明顯改善患者運動的表現
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25患者
義大利
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1. 明顯改善帕金森氏症統一評量表的總分
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Nutrional Neuroscience 2011;14:1-9.
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2. 運動表現分項分數III顯著進步
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3. 顯著減少Hoehn-Yahr改良分期評量表
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二
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服用咖啡因(200-400毫克)6週顯著改善客觀活動的表現
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61患者
加拿大
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1. 明顯改善帕金森氏症統一評量表的總分
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Neurology 2012;79:651-658.
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2. 明顯改善客觀運動表現的分數
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參考文獻：
1、 Bronstein J, Carvey P, Chen H, et al. Meeting report: Consensus statement-Parkinson's disease and the environment: Collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007. Environ. Health Perspect 2009；117(1):117–121.
2、 Richardson JR, Shalat SL, Buckley B, et al. Elevated serum pesticide levels and risk of Parkinson disease. Arch Neurol 2009；66(7):870–875.
3、 Hatcher-Martin JM, Gearing M, Steenland K, e al. Association between polychlorinated biphenyls and Parkinson's disease neuropathology. Neurotoxicology 2012；33(5):1298–1304.
4、 Gao X, Cassidy A, Schwarzschild MA, et al. Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology 2012; 78:1138-1145.
5、 Palacios N, Gao X, McCullough ML, et al. Caffeine and risk of Parkinson's disease in a large cohort of men and women. Mov Disord 2012; 27(10):1276–1282.
6、 Tanaka K, Miyake Y, Fukushima W, et al. Intake of Japanese and Chinese teas reduces risk of Parkinson’s disease. Parkinsonism & related Disorders 2011;17:446-450.
7、 Tan LC, Koh WP, Yuan JM, et al. Differential effects of black tea on risk of Parkinson’s disease in the Singapore Chinese Health Study. Am J Epidemiol 2008;167:553-560.
8、 Pincus JH, Barry KM. Plasma levels of amino acids correlate with motor fluctuations in parkinsonism. Arch Neurol 1987; 44(10):1006–1009.
9、 Astarloa R, Mena MA, Sánchez V, et al. Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease. Clin Neuropharmacol 1992; 15:375-380.
10、 Renoudet VV, Costa-Mallen P, Hopkins E. A diet low in animal fat and rich in N-hexacosanol and fisetin is effective in reducing symptoms of Parkinson's disease. J Med Food 2012; 15(8):758–761.
11、 Baroni L, Bonetto C, Tessan F, et al. Pilot dietary study with normoproteic protein-redistributed plant-food diet and motor performance in patients with Parkinson's disease. Nutr Neurosci 2011; 14(1):1–9.
12、R. B. Postuma, A. E. Lang, R. P. Munhoz, K. Charland, A. Pelletier, M. Moscovich, L. Filla, D. Zanatta, S. R. Romenets, R. Altman, R. Chuang, B. Shah. Caffeine for treatment of Parkinson disease: A randomized controlled trial. Neurology 2012 79(7):651–658.
1、 Bronstein J, Carvey P, Chen H, et al. Meeting report: Consensus statement-Parkinson's disease and the environment: Collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007. Environ. Health Perspect 2009；117(1):117–121.
2、 Richardson JR, Shalat SL, Buckley B, et al. Elevated serum pesticide levels and risk of Parkinson disease. Arch Neurol 2009；66(7):870–875.
3、 Hatcher-Martin JM, Gearing M, Steenland K, e al. Association between polychlorinated biphenyls and Parkinson's disease neuropathology. Neurotoxicology 2012；33(5):1298–1304.
4、 Gao X, Cassidy A, Schwarzschild MA, et al. Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology 2012; 78:1138-1145.
5、 Palacios N, Gao X, McCullough ML, et al. Caffeine and risk of Parkinson's disease in a large cohort of men and women. Mov Disord 2012; 27(10):1276–1282.
6、 Tanaka K, Miyake Y, Fukushima W, et al. Intake of Japanese and Chinese teas reduces risk of Parkinson’s disease. Parkinsonism & related Disorders 2011;17:446-450.
7、 Tan LC, Koh WP, Yuan JM, et al. Differential effects of black tea on risk of Parkinson’s disease in the Singapore Chinese Health Study. Am J Epidemiol 2008;167:553-560.
8、 Pincus JH, Barry KM. Plasma levels of amino acids correlate with motor fluctuations in parkinsonism. Arch Neurol 1987; 44(10):1006–1009.
9、 Astarloa R, Mena MA, Sánchez V, et al. Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease. Clin Neuropharmacol 1992; 15:375-380.
10、 Renoudet VV, Costa-Mallen P, Hopkins E. A diet low in animal fat and rich in N-hexacosanol and fisetin is effective in reducing symptoms of Parkinson's disease. J Med Food 2012; 15(8):758–761.
11、 Baroni L, Bonetto C, Tessan F, et al. Pilot dietary study with normoproteic protein-redistributed plant-food diet and motor performance in patients with Parkinson's disease. Nutr Neurosci 2011; 14(1):1–9.
12、R. B. Postuma, A. E. Lang, R. P. Munhoz, K. Charland, A. Pelletier, M. Moscovich, L. Filla, D. Zanatta, S. R. Romenets, R. Altman, R. Chuang, B. Shah. Caffeine for treatment of Parkinson disease: A randomized controlled trial. Neurology 2012 79(7):651–658.
作者:
陳惟華醫師, 愛家自然診所院長、英國牛津大學神經學博士、醫界蔬食聯盟發起人之一
資料來源：
1. 陳惟華醫師的愛家園地, http://lovingclinic.blogspot.tw/2014/03/blog-post_28.html" target="_blank">蔬食的飲食模式能夠預防和治療帕金森氏症, 2014/03/28
2. 健康醫療網,http://healthnews.com.tw/readblog.php?nid=14155" target="_blank">蔬食的飲食模式能夠預防和治療帕金森氏症, 2014/03/28
http://vegunion.org/node/2839
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